NADIS Academy

Cancer is a group of diseases that may affect anyone at any point in life and can lead to long-lasting changes in our lives. My uncle was diagnosed with melanoma at the age of 33 and passed away seven years later, shortly after his 40th birthday. Since his death, I have been wondering: would it […]

Rubén, what was your personal path into science? What made you decide to focus on metabolism and ageing? Rubén: At that time, I realized that although I was focused on producing these compounds, they might have therapeutic potential. This was around 2012, when the first studies on NR and NMN appeared. So, after finishing my […]

Could you tell us about your scientific journey and what inspired you to investigate the connection between mitochondria signalling and disease? Eija: Well, my mitochondria-related scientific journey started during my PhD studies, when I was investigating mice with accelerated polyamine catabolism. I came across a striking finding that these mice were resistant to diet-induced obesity.I […]

Can you tell us about your scientific journey and what drew you to the biology of NAD⁺, particularly the role of the enzyme CD38? Santina: Yes, my interest in CD38 and NAD⁺ began with my undergraduate thesis, and I’ve continued working in this field throughout my PhD and ever since.Originally, our focus was on what […]

Riekelt, you are the coordinator of the NADIS project. What was the motivation behind creating such a network and what do you hope to achieve with it? Riekelt: This network emerged because we were collaborating with a couple of the people who are now within NADIS, also the PIs, including Morten, Evandro, Carles, and Eija. […]

What inspired you to become a neuroscientist and what interested you in this field? Michela: I’m a neurologist by training. So, when I was in my medical training doing my neurology residency, what I really liked, and I what I was inspired by, was the fact that I was treating patients with devastating effects on […]

NAD⁺ has become increasingly relevant in aging research, primarily due to its well-documented decline with age. Human skin, in particular, shows a notable decrease in NAD⁺ levels, dropping approximately 50% across the adult lifespan1. This age-related reduction of NAD⁺ in the skin is now being recognized as a key factor contributing to visible signs of […]

Nicotinamide adenine dinucleotide (NAD⁺) is a central and indispensable molecule that has been preserved in nearly every cell, from bacteria to humans[1]. It functions as a coenzyme in redox reactions, a substrate for various enzymes, a key player in cellular metabolism, and a signaling molecule.  The fact that NAD⁺ is involved in virtually every critical […]

Gene expression in our cells is constantly changing, influenced by factors like physical activity, diet, stress levels, and more. These external factors alter the cell’s metabolic state and energy availability, which in turn affects gene expression. But how exactly does cellular energy impact the regulation of genes? A key player in this process is NAD⁺ […]

When we think about aging, we often focus on visible signs like wrinkles, gray hair, and decreased energy. However, we are now looking deeper, exploring the molecular changes that occur as we age. Among these, NAD⁺ (nicotinamide adenine dinucleotide) plays a crucial role. This important molecule is at the heart of the NADIS consortium’s research, […]

One day, you might need help going to the bathroom, be unable to tie your own shoes, and struggle to follow a simple conversation. In other words, lose your autonomy and become dependent on other people to take care of you. Notably, this only happens to the lucky ones. The late stages of aging are […]

In the goal of improving our daily health, we tend to remember our doctor’s usual recommendations: a healthy diet, physical activity, 7-8 hours of sleep per night, no smoking, limiting alcohol consumption, etc. Yet, according to influencers (Egle Pavyde, 2024), journalists (David Cox, 2024; Emily Dougherty, 2024), and YouTubers (Rhonda Patrick, 2020), there is a […]

In recent years, there has been a noticeable rise in health consciousness, especially among younger generations. This demographic is increasingly interested in aging and how to slow or even reverse it. Social media platforms like YouTube are showing a trend in anti-aging channels and biohackers sharing their strategies to maintain youthfulness. This surge in interest […]

Obesity, a complex chronic disease characterized by the excessive accumulation of fat, represents one of the major challenges for public health worldwide. In the year 2022, 1/8 of the world population was affected by it. Obesity significantly increases the risk of suffering from type 2 diabetes, cardiovascular diseases, or even certain types of cancer. In […]

NAD⁺-Powered Diet and Lifestyle Tips for Aging Gracefully  Are you looking to boost your energy levels, improve cognitive function, and enhance your overall well-being naturally? The key could lie in increasing the levels of NAD⁺ (Nicotinamide Adenine Dinucleotide) in your body.  Previously, we discussed the biochemical pathways and foundational aspects of NAD⁺ in anti-aging. Now, let’s explore […]

In the quest for eternal youth, scientists have long sought after the elusive key to slowing down the aging process. While the fountain of youth may remain a mythical concept, recent research has uncovered a promising candidate: nicotinamide adenine dinucleotide, or NAD⁺. This molecule, found in every cell of our bodies, plays a crucial role […]

Our bodies have a natural 24-hour cycle called the circadian rhythm, which regulates when we sleep and wake, influencing hormone release, our eating habits, and even our mood. This rhythm makes sure our functions are aligned with the external environment, promoting health and well-being.  Interestingly, the molecule NAD⁺ is essential for the regulation of our […]

Mitochondria, often referred to as the ‘powerhouse of the cell,’ play a pivotal role in converting the food we consume into the essential fuel, ATP (adenosine triphosphate), required for our body’s vital functions. These cellular structures not only produce energy but also serve various critical roles within the cell. In fact, approximately 90% of the […]

The end of 2023 is rapidly approaching, marking the time for reflection and the creation of New Year’s resolutions. Some people adore making them, while others might not share the same enthusiasm. Those who cherish New Year’s resolutions often focus on goals that enhance their overall well-being. Popular examples include getting regular sleep, practicing mindfulness, […]

The life of a PhD candidate can be challenging, especially as an international fellow. You arrive in a completely new place with hope for the best and readiness to face the worst, uncertain about the future. Adjusting to a new reality and interacting with people from diverse backgrounds, speaking different languages, presents its own set […]