Prof. Dr. Santina Bruzzone
Full Professor of Biochemistry, School of Medical and Pharmaceutical Sciences, University of Genova (Italy)
Nationality
Italian
MSc education
Biological Sciences, University of Genova (Italy)
PhD education
Biotechnology applied to Pharmacology and Cellular and Molecular Biotechnology applied to Biomedicine, University of Milan (Italy)
Postdoc education
2001 Post-doctoral position at the Dept of Pharmacology, University of Minnesota, Prof. HC Lee’s lab (Minneapolis, MN). 2002-2005 Post-doctoral position at the Department of Experimental Medicine–Section of Biochemistry, University of Genova (Italy). 2002-2003 Visiting researcher for different periods of time in Prof. AH Guse’s lab (Institute of Biochemistry and Molecular Biology I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), within a collaboration granted by Progetto Vigoni-DAAD.
About
In our lab, we have a number of research projects related to NAD⁺ synthesis and NAD⁺ signalling pathways to identify new therapeutical strategies. The main topics are:
- Modulating CD38 and NAD⁺-derived second messengers in white adipose tissue “browning” (within NADIS)
- Blocking NAD⁺ synthesis, targeting NAMPT and/or NAPRT, in cancer
- Fueling NAD⁺ synthesis to counteract neuroinflammation/neurodegeneration
- Pharmacological inhibition of SIRT6 in skin cancer
- SIRT6 role in skeletal muscle dystrophy
Doctoral Candidates
Raúl Pérez Mato 
Thomas Brochard 
Università di Genova
The University of Genoa (UniGe) is a large, historic public university in Italy, founded in 1481, with campuses in Genoa, Savona, Imperia, and La Spezia. It has a wide range of over 130 degree courses across five schools, and is known for its strengths in areas like computer science, with high international rankings in computer vision and machine learning. UniGe's mission includes advancing education, research, and technology transfer, supported by its extensive library system and research centers.
https://unige.it/en