Thomas Brochard

Maintaining proper NAD⁺ metabolism is crucial for the effective production of energy in mitochondria. Disrupted NAD⁺ metabolism has been associated with various diseases, including obesity and cancer cachexia. Researchers are exploring different approaches to enhance NAD⁺ levels as potential solutions to mitigate the negative impacts of declining NAD⁺ on health. The primary strategies currently under investigation involve (a) supplementing NAD⁺ precursors and (b) inhibiting NAD⁺ consumption. Recently, some consideration has been given to combining NAD⁺ boosters with other medications, such as antioxidants, although this field of study is not yet well-explored. This project aims to develop a comprehensive understanding of the connection between NAD⁺ metabolism and obesity and cancer cachexia and the application of NAD⁺ repletion strategies, either alone or in conjunction with redox modulators, to address these disorders. In addition, the project aims to determine the potential of NAD⁺ depletion as a biomarker for cancer-related cachexia, and possibly lung fibrosis.