| Name: | Santina Bruzzone |
| Nationality: | Italian |
| MSc education: | Biological Sciences, University of Genova (Italy) |
| PhD education: | Biotechnology applied to Pharmacology and Cellular and Molecular Biotechnology applied to Biomedicine, University of Milan (Italy) |
| Postdoc education: | 2001 Post-doctoral position at the Dept of Pharmacology, University of Minnesota, Prof. HC Lee’s lab (Minneapolis, MN). 2002-2005 Post-doctoral position at the Department of Experimental Medicine–Section of Biochemistry, University of Genova (Italy). 2002-2003 Visiting researcher for different periods of time in Prof. AH Guse’s lab (Institute of Biochemistry and Molecular Biology I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), within a collaboration granted by Progetto Vigoni-DAAD. |
| Current position: | Full Professor of Biochemistry, School of Medical and Pharmaceutical Sciences, University of Genova (Italy) |
| DC: | Raúl Pérez Mato |
| Social media handles: | Facebook; LinkedIn |
| Description of my lab’s work: | In our lab, we have a number of research projects related to NAD synthesis and NAD signalling pathways to identify new therapeutical strategies. The main topics are: – Modulating CD38 and NAD-derived second messengers in white adipose tissue “browning” (within NADIS) – Blocking NAD synthesis, targeting NAMPT and/or NAPRT, in cancer – Fueling NAD synthesis to counteract neuroinflammation/neurodegeneration – Pharmacological inhibition of SIRT6 in skin cancer – SIRT6 role in skeletal muscle dystrophy |
| Top 3 publications: | SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma – PubMed (nih.gov) CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues – PubMed (nih.gov) SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells – PubMed (nih.gov) |