Publications

Below find all publications from the Doctoral Candidates of the NADIS consortium:

  1. (to be posted soon)

Below find key publications from labs from the NADIS consortium:

  1. Janssens, G.E., Grevendonk, L., Perez, R.Z. et al. Healthy aging and muscle function are positively associated with NAD+ abundance in humans. Nat Aging 2, 254–263 (2022). https://doi.org/10.1038/s43587-022-00174-3
  2. Janssens GE, Houtkooper RH, Hoeks J. NAD+ to assess health in aging humans. Aging (Albany NY). 2022 Aug 6;14(15):5962-5963. doi: 10.18632/aging.204220. Epub 2022 Aug 6. PMID: 35939337; PMCID: PMC9417223.
  3. Zapata-Pérez R, Wanders RJA, van Karnebeek CDM, Houtkooper RH. NAD+ homeostasis in human health and disease. EMBO Mol Med. 2021 Jul 7;13(7):e13943. doi: 10.15252/emmm.202113943. Epub 2021 May 27. PMID: 34041853; PMCID: PMC8261484.
  4. Zapata-Pérez R, Tammaro A, Schomakers BV, Scantlebery AML, Denis S, Elfrink HL, Giroud-Gerbetant J, Cantó C, López-Leonardo C, McIntyre RL, van Weeghel M, Sánchez-Ferrer Á, Houtkooper RH. Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice. FASEB J. 2021 Apr;35(4):e21456. doi: 10.1096/fj.202001826R. PMID: 33724555.
  5. Pirinen E, Auranen M, Khan NA, Brilhante V, Urho N, Pessia A, Hakkarainen A, Ulla Heinonen JK, Schmidt MS, Haimilahti K, Piirilä P, Lundbom N, Taskinen MR, Brenner C, Velagapudi V, Pietiläinen KH, Suomalainen A. Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy. Cell Metab. 2020 Jul 7;32(1):144. doi: 10.1016/j.cmet.2020.05.020. Erratum for: Cell Metab. 2020 Jun 2;31(6):1078-1090.e5. PMID: 32640244.
  6. Helena Lapatto, Minna Kuusela, Aino Heikkinen, Maheswary Muniandy, Birgitta W. van der Kolk, Swetha Gopalakrishnan, Martin Sandvik, Mark S. Schmidt, Sini Heinonen, Sina Saari, Noora Pöllänen, Juho Kuula, Antti Hakkarainen, Janne Tampio, Tuure Saarinen, Marja-Riitta Taskinen, Nina Lundbom, Per-Henrik Groop, Marja Tiirola, Pekka Katajisto, Marko Lehtonen, Charles Brenner, Jaakko Kaprio, Satu Pekkala, Miina Ollikainen, Kirsi H. Pietiläinen, Eija Pirinen, Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota composition in a twin study, MedRxiv 2022 https://www.medrxiv.org/content/10.1101/2022.04.27.22274380v1
  7. Iannetti EF, Smeitink JAM, Willems PHGM, Beyrath J, Koopman WJH. Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD. Cell Death Dis. 2018 Nov 14;9(11):1135. doi: 10.1038/s41419-018-1179-4. PMID: 30429455; PMCID: PMC6235972.
  8. Perez MJ, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, Al-Shaana R, Kaeser S, Fraschka SA, Jucker M, Zeviani M, Viscomi C, Deleidi M*. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids. Molecular Psychiatry. Mol Psychiatry. 2021 Oct;26(10):5733-5750. doi: 10.1038/s41380-020-0807-4.
  9. Beyrath J, Pellegrini M, Renkema H, Houben L, Pecheritsyna S, van Zandvoort P, van den Broek P, Bekel A, Eftekhari P, Smeitink JAM. KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery. Sci Rep. 2018 Apr 26;8(1):6577. doi: 10.1038/s41598-018-24900-3. PMID: 29700325; PMCID: PMC5920042.
  10. Pérez MJ, Baden P, Deleidi M. Progresses in both basic research and clinical trials of NAD+ in Parkinson’s disease. Review. Mech Ageing Dev 2021 May 11;197:111499. doi: 10.1016/j.mad.2021.111499.
  11. Schöndorf DC, Ivaniuk D, Sanchez-Martinez A, Giunta I, Yu C, De Cicco S, Schwarz LK, Nestel S, Keatinge M, Pruszak J, Bandmann O, Heimrich B, Gasser T, Whitworth AJ, Deleidi M. Nicotinamide riboside rescues mitochondrial defects and neurodegeneration in iPSC and fly models of Parkinson’s disease. Cell Rep. 2018 Jun 5;23(10):2976-2988. doi: 10.1016/j.celrep.2018.05.009
  12. Benzi A, Sturla L, Heine M, Fischer AW, Spinelli S, Magnone M, Sociali G, Parodi A, Fenoglio D, Emionite L, Koch-Nolte F, Mittrücker HW, Guse AH, De Flora A, Zocchi E, Heeren J, Bruzzone S. CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158819. doi: 10.1016/j.bbalip.2020.158819. Epub 2020 Sep 30. PMID: 33010451.
  13. Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD+ in Brain Aging and Neurodegenerative Disorders. Cell Metab. 2019 Oct 1;30(4):630-655. doi: 10.1016/j.cmet.2019.09.001. PMID: 31577933; PMCID: PMC6787556.
  14. Reiten OK, Wilvang MA, Mitchell SJ, Hu Z, Fang EF. Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing. Mech Ageing Dev. 2021 Oct;199:111567. doi: 10.1016/j.mad.2021.111567. Epub 2021 Sep 10. PMID: 34517020.