Author: Admin

  • Maria’s secondment

    During my secondment in the Laboratory of Systems Biology and Genetics at EPFL, I had the unique opportunity to conduct an experiment involving the treatment of murine cells from subcutaneous tissue with NAD+ precursors and a PARP1 inhibitor. The process was highly interesting to me and included: the extraction of the stromal-vascular fraction, FACS sorting…

  • NAD+ and obesity 

    Obesity, a complex chronic disease characterized by the excessive accumulation of fat, represents one of the major challenges for public health worldwide. In the year 2022, 1/8 of the world population was affected by it. Obesity significantly increases the risk of suffering from type 2 diabetes, cardiovascular diseases, or even certain types of cancer. In…

  • Unlocking Youthful Vitality

    NAD+-Powered Diet and Lifestyle Tips for Aging Gracefully  Are you looking to boost your energy levels, improve cognitive function, and enhance your overall well-being naturally? The key could lie in increasing the levels of NAD+ (Nicotinamide Adenine Dinucleotide) in your body.  Previously, we discussed the biochemical pathways and foundational aspects of NAD+ in anti-aging. Now,…

  • Thomas’ secondment

    During this secondment, with the assistance of the NADIS Ph.D. student and theanalysts of the lab, I analyzed different adipocyte samples using the mass spectrometry. This includes 3D adipocyte spheroids and white adipose tissue samples. I have learned how to prepare samples for the mass spectrometry analysis and how to interpret the results obtained from…

  • Boosting NAD+ Levels for Healthy Aging 

    In the quest for eternal youth, scientists have long sought after the elusive key to slowing down the aging process. While the fountain of youth may remain a mythical concept, recent research has uncovered a promising candidate: nicotinamide adenine dinucleotide, or NAD+. This molecule, found in every cell of our bodies, plays a crucial role…

  • Raúl’s secondment

    NAD+ in adipose tissue aging Raúl Pérez Mato, NADIS doctoral candidate at the University of Genoa, performed a secondment at the University of Copenhagen, in Nov-Dec 2023, with the aim of studying NAD+ in white and brown adipose tissue in the context of aging. This secondment represented the first step in a collaboration between the…

  • NAD+ and the Circadian Rhythm 

    Our bodies have a natural 24-hour cycle called the circadian rhythm, which regulates when we sleep and wake, influencing hormone release, our eating habits, and even our mood. This rhythm makes sure our functions are aligned with the external environment, promoting health and well-being.  Interestingly, the molecule NAD+ is essential for the regulation of our…

  • Inspiring the Next Generation

    NADIS Project Engages High School Students in Science The Department of Experimental Medicine actively engages in various initiatives to promote science among the public, particularly targeting high school students. More than 1000 students are offered hands-on laboratory experiences through visits to the state-of-the-art laboratory at the Polo Biotechnology at UNIGE. These experiences aim to guide…

  • French Society for Stem Cell Research Meeting 2024

    Our brilliant PhD candidate, Federico Bertoli, representing the Imagine Institut in Paris, shared his latest work at the French Society for Stem Cell Research Meeting 2024. He showed his progresses in developing a model to better understand Parkinson’s disease. His goal is to explain how the alpha-synuclein protein and NAD+ metabolism are linked in this…

  • What Happens When the Cell’s Powerhouse Fails? Understanding Mitochondrial Dysfunction

    Mitochondria, often referred to as the ‘powerhouse of the cell,’ play a pivotal role in converting the food we consume into the essential fuel, ATP (adenosine triphosphate), required for our body’s vital functions. These cellular structures not only produce energy but also serve various critical roles within the cell. In fact, approximately 90% of the…